Enough people are allergic to one or more of the proteins in natural rubber latex (NRL) that certain business segments avoid using latex products so as to not expose employees with latex allergies. For example, in many industries (such as health care and food service) vinyl has replaced latex in disposable gloves. Most of the latex allergens are removed by washing and/or rinsing in the process of making latex foam, but they remain in many other applications.

In 2001, chemical engineer and entrepreneur Travis Honeycutt founded Vystar Corp. with the mission of producing liquid NRL with virtually no allergens. Vystar scientists and engineers worked on research and development. They had a product in 2007, and worked on manufacturing and distribution by licensing producers. In 2016, Vystar was able to announce the global availability of Vytex® Natural Rubber Latex, an allergy-free latex.

Latex foam made with Vytex is now available to mattress manufacturers. For example, Gold Bond Mattress Company uses Vytex NRL foam in several of its mattresses.